USO DA DOXICICLINA COMO ADJUVANTE À TERAPIA PERIODONTAL NÃO-CIRÚRGICA
Parole chiave:
Periodontia, Doenças Periodontais, DoxiciclinaAbstract
Objetivo: expor as vantagens, desvantagens e indicações do uso sistêmico e local da doxiciclina como tratamento auxiliar das doenças periodontais inflamatórias. Métodos: O presente estudo se trata de uma revisão bibliográfica, sobre o uso da doxiciclina em periodontia, realizada por meio de uma pesquisa exploratória. Resultados: A administração local do hiclato gel 10% de doxiciclina age diretamente nas bolsas periodontais, garantindo uma efetividade antimicrobiana de 7 a 14 dias. A administração antimicrobiana de 100mg, 1x ao dia, durante 30 dias apresentou melhoras significativas nos índices de biofilme dentário, inflamação gengival, profundidade de sondagem e sangramento à sondagem. Conclusão: A administração da doxiciclina como antimicrobiano, quando bem indicada, auxilia no tratamento da doença periodontal, porém não substitui a parte mecânica de raspagem e alisamento radicular.
Riferimenti bibliografici
AGARWAL, A.; GUPTA, N. D. Combination of bone allograft, barrier membrane and doxycycline in the treatment of infrabony periodontal defects: A comparative trial. The Saudi Dental Journal, pages 6, may, 2015.
ALMEIDA, R. F. et. al. Associação entre doença periodontal e patologias sistêmicas.
Rev Port Clin Geral, 2006;22:379-90.
ALMEIDA, R. M. et. al. Uso de Antimicrobianos Sistêmicos e Locais no Tratamento da Periodontite Agressiva. Oral Sciences, Jan/Jun. 2014, vol. 6, n. 1, p. 4-9.
ANDRADE, D.P. et. al. A doxiciclina como adjuvante no tratamento da periodontite.
Int J Dent, 8(4):202-210, out/dez., 2009.
BISCARDE, A. O. et. al. Diretrizes para a utilização adjunta da antibioticoterapia sistêmica no tratamento das doenças periodontais. Innov Implant J, Biomater Esthet, São Paulo, v. 5, n. 2, p. 51-59, maio/ago. 2010.
BOGDANOVSKA, L. et.al. Efficacy assessment of local doxycycline treatment in periodontal patients using multivariate chemometric approach. European Journal of Pharmaceutical Sciences, 91 (2016) 114–121.
CABALLERO, A. J. D.; RICAURTE, M. A. F.; CONRADO, C. E. P. Cálculo dental una
revisión de literatura y presentación inusual. Acta Odontológica Venezolana, Vol 49, nº 3, 2011.
CARRANZA, F. A. et. al. Periodontia Clínica. Ed11. Elsevier Editora Ltda, 2011.
EICKHOLZ, P. et. al. Non-surgical periodontal therapy with adjunctive topical doxycyxline: a double-blind randomized controlled multicenter study. (I). Study design and clinical results. J Clin Periodontol, 2002;29:108-117.
EMINGIL, G. et. al. Adjunctive Effects of a Sub-Antimicrobial Dose of Doxycycline on Clinical Parameters and Potential Biomarkers of Periodontal Tissue Catabolism.
Dentistry Journal, January, 2019.
FALKENSTEIN, S. et. al. Trends in antibiotic use and microbial diagnostics in periodontal treatment: comparing surveys of German dentists in a ten-year period. Clin Oral Invest, January, 2016.
FAVERI, M. et. al. Controle da placa bacteriana supragengival na terapia periodontal não- cirúrgica. Revista de Odontologia da UNESP, 2006; 35(4): 313-18.
GAD, H. A. et. al. Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: Development, in-vitro and in-vivo clinical evaluation. Expert Opinion on Drug Delivery, may, 2017.
GAMAL, A. Y.; KUMPER, R. M.; GENDY ABD EL R R. AL. Doxycycline-Loaded b-Tricalcium Phosphate Release Following EDTA Root Surface Etching Improved the Clinical Outcomes in Chronic Periodontitis: An In Vivo Study. J Periodontol, 2013;84:924-933.
GARRETT, S. et. al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol, 1999 May;70(5):490-503.
GOLUB, L. M. et. al. Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases. International Dental Journal, 2016; 66: 127–135.
IOANNOU, I. et. al. The effect of locally delivered, doxycycline in the treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study. Journal of Oral & Maxillofacial Research, 2010.
KEESTRA, J. A. J. et. al. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. Journal of Periodontal Research, 2014.
KHATRRI, S. et. al. Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis. John Wiley & Sons, 2020.
MADI, M. et. al. The anti-inflammatory effect of locally delivered nano-doxycycline gel in therapy of chronic periodontitis. Acta Odontologica Scandinavica, 2017.
MOMBELLI, A. et. al. Topical and systemic antibiotics in the management of periodontal diseases. International Dental Journal, (2004) 54, 3–14
MOURA, L. A.et. al. Characterization of the release profile of doxycycline by PLGA microspheres adjunctto non surgical periodontal therapy. Journal of Biomaterials Science, June, 2015.
OLIVEIRA, I. L. M.; et. al. Antimicrobianos de uso odontológico: informação para uma boa prática. Odontol. Clín.-Cient., Recife, 10 (3) 217-220, jul./set., 2011
PARK, J. Low dose of doxycycline promotes early differentiation of preosteoblasts by partially regulating the expression of estrogen receptors. Journal of surgical research, 178 (2012) 737 e 742.
SHEHWARO, N. et. al. La doxycycline ou comment faire du neuf avec du vieux?
Pharmacologie clinique, Mars/Avril, 2014.
SPASOVSKI, S. et. al. Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease. Open Access Maced J Med Sci., 2016 Mar 15; 4(1):152-157.
TEUGHELS, W. et. al. Treatment of aggressive periodontitis. Periodontology 2000,Vol. 65, 2014, 107–133.
ALMEIDA, R. F. et. al. Associação entre doença periodontal e patologias sistêmicas.
Rev Port Clin Geral, 2006;22:379-90.
ALMEIDA, R. M. et. al. Uso de Antimicrobianos Sistêmicos e Locais no Tratamento da Periodontite Agressiva. Oral Sciences, Jan/Jun. 2014, vol. 6, n. 1, p. 4-9.
ANDRADE, D.P. et. al. A doxiciclina como adjuvante no tratamento da periodontite.
Int J Dent, 8(4):202-210, out/dez., 2009.
BISCARDE, A. O. et. al. Diretrizes para a utilização adjunta da antibioticoterapia sistêmica no tratamento das doenças periodontais. Innov Implant J, Biomater Esthet, São Paulo, v. 5, n. 2, p. 51-59, maio/ago. 2010.
BOGDANOVSKA, L. et.al. Efficacy assessment of local doxycycline treatment in periodontal patients using multivariate chemometric approach. European Journal of Pharmaceutical Sciences, 91 (2016) 114–121.
CABALLERO, A. J. D.; RICAURTE, M. A. F.; CONRADO, C. E. P. Cálculo dental una
revisión de literatura y presentación inusual. Acta Odontológica Venezolana, Vol 49, nº 3, 2011.
CARRANZA, F. A. et. al. Periodontia Clínica. Ed11. Elsevier Editora Ltda, 2011.
EICKHOLZ, P. et. al. Non-surgical periodontal therapy with adjunctive topical doxycyxline: a double-blind randomized controlled multicenter study. (I). Study design and clinical results. J Clin Periodontol, 2002;29:108-117.
EMINGIL, G. et. al. Adjunctive Effects of a Sub-Antimicrobial Dose of Doxycycline on Clinical Parameters and Potential Biomarkers of Periodontal Tissue Catabolism.
Dentistry Journal, January, 2019.
FALKENSTEIN, S. et. al. Trends in antibiotic use and microbial diagnostics in periodontal treatment: comparing surveys of German dentists in a ten-year period. Clin Oral Invest, January, 2016.
FAVERI, M. et. al. Controle da placa bacteriana supragengival na terapia periodontal não- cirúrgica. Revista de Odontologia da UNESP, 2006; 35(4): 313-18.
GAD, H. A. et. al. Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: Development, in-vitro and in-vivo clinical evaluation. Expert Opinion on Drug Delivery, may, 2017.
GAMAL, A. Y.; KUMPER, R. M.; GENDY ABD EL R R. AL. Doxycycline-Loaded b-Tricalcium Phosphate Release Following EDTA Root Surface Etching Improved the Clinical Outcomes in Chronic Periodontitis: An In Vivo Study. J Periodontol, 2013;84:924-933.
GARRETT, S. et. al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol, 1999 May;70(5):490-503.
GOLUB, L. M. et. al. Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases. International Dental Journal, 2016; 66: 127–135.
IOANNOU, I. et. al. The effect of locally delivered, doxycycline in the treatment of Chronic Periodontitis. A Clinical and Microbiological Cohort Study. Journal of Oral & Maxillofacial Research, 2010.
KEESTRA, J. A. J. et. al. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. Journal of Periodontal Research, 2014.
KHATRRI, S. et. al. Adjunctive systemic antimicrobials for the non-surgical treatment of periodontitis. John Wiley & Sons, 2020.
MADI, M. et. al. The anti-inflammatory effect of locally delivered nano-doxycycline gel in therapy of chronic periodontitis. Acta Odontologica Scandinavica, 2017.
MOMBELLI, A. et. al. Topical and systemic antibiotics in the management of periodontal diseases. International Dental Journal, (2004) 54, 3–14
MOURA, L. A.et. al. Characterization of the release profile of doxycycline by PLGA microspheres adjunctto non surgical periodontal therapy. Journal of Biomaterials Science, June, 2015.
OLIVEIRA, I. L. M.; et. al. Antimicrobianos de uso odontológico: informação para uma boa prática. Odontol. Clín.-Cient., Recife, 10 (3) 217-220, jul./set., 2011
PARK, J. Low dose of doxycycline promotes early differentiation of preosteoblasts by partially regulating the expression of estrogen receptors. Journal of surgical research, 178 (2012) 737 e 742.
SHEHWARO, N. et. al. La doxycycline ou comment faire du neuf avec du vieux?
Pharmacologie clinique, Mars/Avril, 2014.
SPASOVSKI, S. et. al. Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease. Open Access Maced J Med Sci., 2016 Mar 15; 4(1):152-157.
TEUGHELS, W. et. al. Treatment of aggressive periodontitis. Periodontology 2000,Vol. 65, 2014, 107–133.
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2021-08-10
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